Karachi is home to a vibrant civil society. Civil society groups are actively engaged in contributing to the betterment of the city and its people in a variety of thematic areas. These include human rights, environment, community development, health and education, youth empowerment to name a few. They act as advocacy activists, watchdog groups working for transparency in governance, for empowerment of the marginalized communities and in training and action research. Similarly, academic institutions are increasingly finding an outreach within the communities, researching and documenting critical urban development challenges, indicators and offering training, capacity building and innovative solutions to the city’s growth related challenges. Here, we document some leading non-governmental organizations and academic institutions of the city and their areas of focus.